当马来酸酐作为杂质存在于邻苯二甲酸酐中的具体危害
毒性协同与风险放大：
更强的整体刺激性：混合物对人体的眼、鼻、喉、肺的刺激作用会因MA的存在而加剧。工人在接触含有MA杂质的PA时，可能更快出现流泪、咳嗽、咽喉痛等症状。
更高的致敏风险：两者都是致敏原，MA的存在可能使产品整体的致敏能力增强，导致工人发展成职业性哮喘的风险和速度增加。
未知的长期健康风险：由于MA被怀疑具有遗传毒性和潜在致癌性，长期接触含有该杂质的PA产品，可能会增加额外的长期健康风险，这是纯PA所不具备的。
对产品质量与加工安全的影响：
更高的反应活性：MA的化学活性比PA更高，可能在某些下游化学反应（如聚酯、醇酸树脂生产）中导致不可预见的副反应，影响最终产品的色泽、稳定性和性能。
储存与处理风险：MA杂质的存在可能使物料对水分更加敏感（因MA水解更快），增加了在潮湿环境下结块、变质或产生腐蚀性气体的风险。
浩瀚色谱（山东）应用技术开发有限公司利用气相色谱对邻苯二甲酸酐中有机杂质进行分离,用氢火焰离子化检测器进行检测,峰面积外标法进行定量分析。对该方法的准确度、度、检出限数据进行了评价。
名称：毛细管柱
型号：HH-1701
规格：30m*0.25mm*0.25um
温度：280°C
应用：SNT 4373-2015 邻苯二甲酸酐中马来酸酐的测定气相色谱法
应用：
安捷伦490在线/便携，4890,5890,6890,7820,7890,8860,8890
岛津GC-14C，GC-2010，GC-2014，GC-2030
赛默飞1310,1300,1610,1600
瓦里安3800系列
布鲁克PE580,590,680,690
磐诺A90，福立GC9790，华爱，天瑞，天美，GC7900，川仪，北分瑞利，东西电子，鲁南瑞虹，捷岛/科晓
Specific hazards when maleic anhydride exists as an impurity in phthalic anhydride
Toxicity synergy and risk amplification:
Stronger overall stimulation: The stimulating effect of the mixture on the eyes, nose, throat, and lungs of the human body will be exacerbated by the presence of MA. Workers may experience symptoms such as tearing, coughing, and sore throat more quickly when exposed to PA containing MA impurities.
Higher sensitization risk: Both are allergens, and the presence of MA may enhance the overall sensitization ability of the product, leading to an increased risk and speed of workers developing occupational asthma.
Unknown long-term health risks: Due to the suspected genotoxicity and potential carcinogenicity of MA, long-term exposure to PA products containing this impurity may increase additional long-term health risks, which pure PA does not possess.
The impact on product quality and processing safety:
Higher reactivity: MA has a higher chemical reactivity than PA and may cause unforeseen side reactions in certain downstream chemical reactions (such as polyester and alkyd resin production), affecting the color, stability, and performance of the final product.
Storage and handling risks: The presence of MA impurities may make the material more sensitive to moisture (due to faster hydrolysis of MA), increasing the risk of clumping, deterioration, or the production of corrosive gases in humid environments.
Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. uses gas chromatography to separate organic impurities in phthalic anhydride, detects them using a hydrogen flame ionization detector, and quantitatively analyzes them using peak area external standard method. The accuracy, precision, and detection limit data of the method were evaluated.
Name: Capillary Column
Model: HH-1701
Specification: 30m * 0.25mm * 0.25um
Temperature: 280 ° C
Application: SNT 4373-2015 Determination of maleic anhydride in phthalic anhydride Gas chromatography method
Application:
Agilent 490 online/portable, 48905890689088608890
Shimadzu GC-14C, GC-2010, GC-2014, GC-2030
Thermo Fisher Scientific 1310130016101600
Varian 3800 Series
Brooke PE580590680690
Panno A90, Fuli GC9790, Huaai, Tianrui, Tianmei, GC7900， Chuanyi, Beifen Ruili, Dongxi Electronics, Lunan Ruihong, Jiedao/Kexiao
滕州市浩瀚色谱仪器技术服务有限公司
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传真：0632-5667636
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